Cover of: Epithelial Morphogenesis in Development and Disease (Cell Adhesion and Communication) | Walter Birchmeier

Epithelial Morphogenesis in Development and Disease (Cell Adhesion and Communication)

  • 449 Pages
  • 3.43 MB
  • English
Cellular biology, Histology, Human biology, Molecular biology, Science/Mathematics, Medical / Nursing, Science, Life Sciences - Biology - Molecular Biology, Microbiology, Science / Molecular Biology, Life Sciences - Biology - Ge
The Physical Object
ID Numbers
Open LibraryOL9106890M
ISBN 109057024195
ISBN 139789057024191

Epithelial Morphogenesis in Development and Disease. DOI link for Epithelial Morphogenesis in Development and Disease. Epithelial Morphogenesis in Development and Disease book. By Walter Birchmeier. Edition 1st Edition. First Published eBook Published 2 September Pub.

location London. Imprint CRC by:   Epithelial Morphogenesis in Development and Disease (Cell Adhesion and Communication) 1st Edition by Walter Birchmeier (Author) ISBN Cited by: Epithelial-Mesenchymal Signaling in the Regulation of Epithelial Morphogenesis and Apoptosis during Tooth Development \/ A.

Vaahtokari and I. Thesleff. Biological Functions of GAP Junction Channels Revealed by Targeted Connexin Deficient Mice \/ K. Willecke and T. Ott -- C.

Epithelia in Disease. Precisely how epithelial cells come together to form epithelial sheets and how these dynamic structures constantly remodel so as to maintain their barrier function is an outstanding question in development and diseases of adults (cancer, bacterial infection, chronic inflammatory disease).

Electronic books: Additional Physical Format: Print version: Epithelial morphogenesis in development and disease. Amsterdam: Harwood Academic, © (OCoLC) Material Type: Document, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: W Birchmeier; Carmen Birchmeier.

The epithelial–mesenchymal transition (EMT) is a fundamental process governing morphogenesis in multicellular organisms. This process is also reactivated in a variety of diseases including fibrosis and in the progression of carcinoma.

Purchase Tissue Remodeling and Epithelial Morphogenesis, Volume 89 - 1st Edition. Print Book & E-Book. ISBN  Epithelial-Mesenchymal Transitions in Development and Disease.

EMT on drug resistance Epithelial Morphogenesis in Development and Disease book explore recent findings that reinforce the concept of EMT as a major driver of morphogenesis and tumor progression. a mesenchymal state is required to maintain stemness opens new avenues to understand epithelial plasticity in health and disease.

Epithelial-to-mesenchymal transitions (EMTs) are complex cellular processes where cells undergo dramatic changes in signaling, transcriptional programming, and cell shape, while directing the exit of cells from the epithelium and promoting migratory properties of the resulting mesenchyme.

EMTs are essential for morphogenesis during development and are also a critical step in cancer progression. These regulate the advancing morphogenesis of the tooth crown and control the initiation of the secondary enamel knots at the sites of epithelial foldings that mark cusp formation.

An early signalling event in tooth development is the induction of the odontogenic. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes.

Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. During development, the precise control of tissue morphogenesis requires changes in the cell number, size, shape, position, and gene expression, which are driven by both chemical and mechanical cues from the surrounding microenvironment.

Such physical and architectural features inform cells about their proliferative and migratory capacity, enabling the formation and maintenance of complex.

Phosphatase and tensin homolog (PTEN) is one of the most frequently mutated tumor suppressor genes in human cancers. PTEN germline mutations cause tumor predisposition syndromes such as Cowden disease (Sansal and Sellers, ).In mice, global deletion of the Pten gene arrests embryonic development between embryonic day (E) and E, depending upon domains disrupted and.

Purchase Cellular Adhesion in Development and Disease, Volume - 1st Edition.

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Print Book & E-Book. ISBNBiliary differentiation and bile duct morphogenesis in development and disease. a specialized epithelial cell type that has a dual origin. Intrahepatic cholangiocytes derive from the liver precursor cells, whereas extrahepatic cholangiocytes are generated directly from the endoderm.

In this review we discuss the mechanisms of. The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and continuously undergoes controlled remodelling. This process involves quantitative and qualitative changes in the ECM, mediated by specific enzymes that are responsible for ECM degradation, such as metallo.

As discussed previously, biomechanical properties can have significant influence on morphogenesis of epithelial cells in vivo, in vitro and in disease state. Of interest to this review, the epiblast tissue achieves a fully epithelized state before gastrulation EMT takes place. The epithelial–mesenchymal transition: new insights in signaling, development, and disease.

The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. Current interest in this process, which is described as an epithelial–mesenchymal transition (EMT), stems from its developmental.

Finally, the morphogenesis of the extrahepatic ducts depends on the coordinated development of epithelial and mesenchymal cells. The lack of HNF-6 or HNF-1β in cholangiocytes and haploinsufficiency of the transcription factor FoxF1 in the mesenchyme are associated with gallbladder and common bile duct dysgenesis (Clotman et al., Increased understanding of branching morphogenesis in the breast gland and the regulation of EMT and its reverse process mesenchymal to epithelial transition (MET) may hold the keys for future development of methods/drugs that neutralize the invading properties of cancer cells.

Numerous epithelia undergo tubulogenesis and branching morphogenesis during their development (i.e., lung, salivary gland, pancreas) in order to establish sufficient available surface for their proper functioning.

The thymus is a primary lymphoid organ constituted by pharyngeal-derived epithelium necessary to produce immunocompetent lymphocytes whose mechanisms of development are not.

book are believed to be true and accurate at the date of publication. its epithelial tissue must undergo morphogenesis to generate functioning nephric tubes.

7 Development and Diseases of.

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Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity.

Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. WNT10A (Wingless-type MMTV integration site family, member 10A) plays a crucial role in tooth development, and patients with biallelic WNT10A mutation and mice lacking Wnt10a show taurodontism.

However, whether epithelial or mesenchymal WNT10A controls the initiation of the root furcation formation remains unclear, and the functional significance of WNT10A in regulating root morphogenesis.

Multiple components of the Wnt signaling pathway have been implicated to play a role in lung formation. 43, 44 The loss of Wnt5a expression in mice causes overexpansion of the distal epithelial airways and thickening of the mesenchymal interstitium.

25 Conversely, the transgenic expression of Wnt5a during early lung development resulted in.

Description Epithelial Morphogenesis in Development and Disease (Cell Adhesion and Communication) PDF

The role played by epithelial cells was revisited in more detail only 15 yrs ago, and their response to inflammation and damage have been clearly found to be abnormal in asthma 3.

Allergens are potential deleterious factors that may interact and injure bronchial epithelium, leading to the development of long-term diseases such as asthma.

Introduction. Sonic hedgehog (SHH) is a fundamental morphogenesis pathway. Its members and regulation have been extensively reviewed elsewhere (see [] and Toftgard, this issue).The fundamental importance of SHH in organogenesis was demonstrated in mis-expression and knockout mice studies which showed its role in patterning the brain, spinal cord, axial skeleton, limbs and epithelial.

Of the nearly two-thirds of Ets factors genetically inactivated in the mouse thus far (Table 1), only one, the epithelial-specific Ets factor Elf3, has been reported to have an intestinal phenotype (Ng et al., ).Elf3 −/− embryos manifest delayed and impaired villus morphogenesis, impaired enterocyte differentiation and altered microvillus structure, and altered goblet cell differentiation.

Ocular morphogenesis in zebrafish. Neuro TV. Follow. 2 years ago | 2 views. In their latest paper in Development, Link and colleagues examined the roles of Hippo signalling components during zebrafish eye development, showing that Report.

Browse more videos. Hair follicle morphogenesis depends on Wnt, Shh, Notch, BMP and other signaling pathways interplay between epithelial and mesenchymal cells. The Wnt pathway plays an essential role during hair follicle induction, Shh is involved in morphogenesis and late stage differentiation, Notch signaling determines stem cell fate while BMP is involved in cellular differentiation.

Introduction. Semaphorins are guidance proteins that influence cellular morphology and function, and play important roles in organogenesis and disease [].Semaphorins, initially identified as axon repellents and subsequently recognized as attractant and repellent cues for multiple cell types, are phylogenetically conserved from C.

Elegans to humans. Semaphorin proteins are defined by a common.M3 - Chapter (Book) AN - SCOPUS SN - T3 - Results and Problems in Cell Differentiation. SP - EP - BT - Kidney Development and Disease.

A2 - Miller, Rachel K. PB - Springer-Verlag London Ltd. ER .Developmental branching morphogenesis establishes organ architecture, and it is driven by iterative interactions between epithelial and mesenchymal progenitor cell populations. We describe an approach for analyzing this interaction and how it contributes to organ development.

After initial in vivo c .